吴伊丽教授 |
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吴伊丽，教授，硕士研究生导师，济宁医学院精神卫生学院副院长、精神医学研究院常务副院长、山东省出生缺陷研究与转化协同创新中心副主任。2003年获得天津医科大学内科学博士学位；2004年至2007年，作为博士后在加拿大McMaster University 从事衰老研究；2007年至2015年先后作为博士后和副研究员在加拿大The University of British Columbia从事阿尔茨海默病及相关疾病的研究。2015年加入济宁医学院精神卫生学院。先后主持或参加中国国家自然科学基金、加拿大Natural Science and Engineering Research Council of Canada (NSERC)和Canadian Institutes of Health Research (CIHR)等项目。在Nature Structural & Molecular Biology、The Journal of Clinical Investigation，Molecular Psychiatry和Acta Neuropathologica等期刊发表SCI论文30余篇，论文引用600余次。
代表论著
1.Zhang, X., et al., Regulation of global gene expression in brain by TMP21. Mol Brain, 2019. 12(1): p. 39.
2.Zhang, Q., et al., The association of GABRB2 SNPs with cognitive function in schizophrenia. Eur Arch Psychiatry Clin Neurosci, 2019.
3.Wang, Z., et al., BACE2, a conditional beta-secretase, contributes to Alzheimer's disease pathogenesis. JCI Insight, 2019. 4(1).
4.Liu, Y., et al., Predictors of depressive symptoms in college students: A systematic review and meta-analysis of cohort studies. J Affect Disord, 2019. 244: p. 196-208.
5.Zhang, X., et al., A Novel Alzheimer-Associated SNP in Tmp21 Increases Amyloidogenesis. Mol Neurobiol, 2018. 55(3): p. 1862-1870.
6.Zhang, S., et al., A presenilin-1 mutation causes Alzheimer disease without affecting Notch signaling. Mol Psychiatry, 2018.
7.Wu, F., et al., Apelin-13 attenuates ER stress-mediated neuronal apoptosis by activating Galphai/Galphaq-CK2 signaling in ischemic stroke. Exp Neurol, 2018. 302: p. 136-144.
8.Kong, Q., et al., HDAC4 in ischemic stroke: mechanisms and therapeutic potential. Clin Epigenetics, 2018. 10(1): p. 117.
9.Guo, K., et al., Expanded Newborn Screening for Inborn Errors of Metabolism and Genetic Characteristics in a Chinese Population. Front Genet, 2018. 9: p. 122.
10.Fu, Q. and Y. Wu, RCAN1 in the inverse association between Alzheimer's disease and cancer. Oncotarget, 2018. 9(1): p. 54-66.
11.Zhang, S., et al., BACE1 Cleavage Site Selection Critical for Amyloidogenesis and Alzheimer's Pathogenesis. J Neurosci, 2017. 37(29): p. 6915-6925.
12.Zeng, J., et al., Marginal vitamin A deficiency facilitates Alzheimer's pathogenesis. Acta Neuropathol, 2017. 133(6): p. 967-982.
13.Wu, Y., et al., Temporal Expression of Apelin/Apelin Receptor in Ischemic Stroke and its Therapeutic Potential. Front Mol Neurosci, 2017. 10: p. 1.
14.Wang, X., et al., Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease. Front Mol Neurosci, 2017. 10: p. 294.
15.Qiu, J., et al., Low Dose of Apelin-36 Attenuates ER Stress-Associated Apoptosis in Rats with Ischemic Stroke. Front Neurol, 2017. 8: p. 556.
16.Luo, Y., et al., Mild traumatic brain injury induces memory deficits with alteration of gene expression profile. Sci Rep, 2017. 7(1): p. 10846.
17.Li, Y., et al., Anti-N-Methyl-d-Aspartate Receptor Encephalitis in a Patient with Alcoholism: A Rare Case Report. Front Psychiatry, 2017. 8: p. 141.
18.Wu, Y., et al., Regulation of global gene expression and cell proliferation by APP. Sci Rep, 2016. 6: p. 22460.
19.Wu, Y., et al., Aberrant Expression of Histone Deacetylases 4 in Cognitive Disorders: Molecular Mechanisms and a Potential Target. Front Mol Neurosci, 2016. 9: p. 114.
20.Zhang, X., et al., Upregulation of SET expression by BACE1 and its implications in Down syndrome. Mol Neurobiol, 2015. 51(2): p. 781-90.
21.Wu, Y., et al., Amyloid-beta precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit alpha type-5 and proteasome subunit beta type-7. Neurobiol Aging, 2015. 36(1): p. 169-77.
22.Li, G., et al., Inhibition of actin polymerization in the NAc shell inhibits morphine-induced CPP by disrupting its reconsolidation. Sci Rep, 2015. 5: p. 16283.
23.Zhang, S., et al., Down-regulation of MIF by NFkappaB under hypoxia accelerated neuronal loss during stroke. FASEB J, 2014. 28(10): p. 4394-407.
24.Wu, Y., Q. Xu, and W. Song, Oxidative Stress and Alzheimer’s Disease, in Systems Biology of Free Radicals and Antioxidants, I. Laher, Editor. 2014, Springer Berlin Heidelberg: Berlin, Heidelberg. p. 2147-2174.
25.Wu, Y., P.T. Ly, and W. Song, Aberrant expression of RCAN1 in Alzheimer's pathogenesis: a new molecular mechanism and a novel drug target. Mol Neurobiol, 2014. 50(3): p. 1085-97.
26.Wang, K., et al., Transcriptional regulation of human USP24 gene expression by NF-kappa B. J Neurochem, 2014. 128(6): p. 818-28.
27.Sun, X., et al., RCAN1 overexpression exacerbates calcium overloading-induced neuronal apoptosis. PLoS One, 2014. 9(4): p. e95471.
28.Duan, X., et al., Upregulation of human PINK1 gene expression by NFkappaB signalling. Mol Brain, 2014. 7: p. 57.
29.Yang, Y., et al., High glucose promotes Abeta production by inhibiting APP degradation. PLoS One, 2013. 8(7): p. e69824.
30.Wu, Y. and W. Song, Regulation of RCAN1 translation and its role in oxidative stress-induced apoptosis. FASEB J, 2013. 27(1): p. 208-21.
31.Ly, P.T., et al., Inhibition of GSK3beta-mediated BACE1 expression reduces Alzheimer-associated phenotypes. J Clin Invest, 2013. 123(1): p. 224-35.
32.Liu, X., et al., BACE2 degradation mediated by the macroautophagy-lysosome pathway. Eur J Neurosci, 2013. 37(12): p. 1970-7.
33.Deng, Y., et al., Amyloid-beta protein (Abeta) Glu11 is the major beta-secretase site of beta-site amyloid-beta precursor protein-cleaving enzyme 1(BACE1), and shifting the cleavage site to Abeta Asp1 contributes to Alzheimer pathogenesis. Eur J Neurosci, 2013. 37(12): p. 1962-9.
34.Sun, X., et al., Regulator of calcineurin 1 (RCAN1) facilitates neuronal apoptosis through caspase-3 activation. J Biol Chem, 2011. 286(11): p. 9049-62.
35.Wu, Y., T.R. Mitchell, and X.D. Zhu, Human XPF controls TRF2 and telomere length maintenance through distinctive mechanisms. Mech Ageing Dev, 2008. 129(10): p. 602-10.
36.Wu, Y., et al., XPF with mutations in its conserved nuclease domain is defective in DNA repair but functions in TRF2-mediated telomere shortening. DNA Repair (Amst), 2007. 6(2): p. 157-66.
37.Wu, Y., S. Xiao, and X.D. Zhu, MRE11-RAD50-NBS1 and ATM function as co-mediators of TRF1 in telomere length control. Nat Struct Mol Biol, 2007. 14(9): p. 832-40.